DEVELOPMENT OF NOVEL 1, 3, 4-THIADIAZOLES AS ANTITUBERCULAR AGENTS-SYNTHESIS AND IN VITRO SCREENING

Synthesis of Some 4-Thiazolidinone Derivatives as Antitubercular Agents

Substituted Schiff's bases 2a-o prepared by the treatment of 2-amino-4-(?-methoxyiminocarbomethoxymethyl)-thiazole 1 with different aromatic aldehydes, on cyclocondensation with mercaptoaceticacid and mercaptopropionicacid in dry benzene furnished desired thiazolidinones of type 3a-o and 4a-j, respectively. The structure of the compounds have been assigned on the basis of elemental analyses and...

Synthesis, In vitro Antimicrobial and Cytotoxic Activities of Some Novel Bis- 1, 3, 4-oxadiazoles

A series of novel bis-1,3,4-oxadizaoles were synthesized by oxidative cyclisation of respective Schiff bases derived from dicarbohydrazide using ceric ammonium nitrate (CAN) as catalyst. The synthesized compounds were screened for in vitro antibacterial activity against Staphylococcus aureus (MTCC 87), Escherichia coli (MTCC 46) and antifungal activity against Candida albicans (NCIM 3471) by tw...

synthesis of some 4-thiazolidinone derivatives as antitubercular agents

substituted schiff's bases 2a-o prepared by the treatment of 2-amino-4-(?-methoxyiminocarbomethoxymethyl)-thiazole 1 with different aromatic aldehydes, on cyclocondensation with mercaptoaceticacid and mercaptopropionicacid in dry benzene furnished desired thiazolidinones of type 3a-o and 4a-j, respectively. the structure of the compounds have been assigned on the basis of elemental analyse...

In-silico Design, Synthesis and in Vitro Antitubercular Activity of Novel 1, 2, 4 - Triazole Derivatives

Objective: To design, synthesize and in vitro anti tubercular evaluation of some new 1,2,4–triazole derivatives. Methods: Novel 1,2,4–triazole derivatives were designed by using various softwares like ACD Lab Chemsketch, Molinspiration, Prediction of activity spectra for substances(PASS) and Schrodinger Glide XP (Grid based ligand docking with energetics). The designed molecules having required...

synthesis, in vitro antimicrobial and cytotoxic activities of some novel bis- 1, 3, 4-oxadiazoles